Vitamin-B Therapy Benefit Diabetics?

Studies have shown that high doses of Vitamin-B do aid heart disease prevention. Meanwhile, many researchers also believed Vitamin-B therapy using folic acid, Vitamin B6, and Vitamin B12 could reduce diabetic kidney damage because Vitamin-B can help lower blood levels of homocysteine.

Homocysteine is an amino acid that induces clotting in the blood and damages the lining of arteries. It is also a strong risk factor for stroke and heart attack. Diabetics are known to have higher homocysteine levels, on average, than people without diabetes.

But, the findings of researchers from the University of Western Ontario and the Robarts Research Institute in London, Ontario seem to be quite different.

In their paper published in the April 28 edition of the Journal of the American Medical Association (JAMA), they reported that patients with diabetic nephropathy might suffer rapid deterioration of their kidneys, if they were treated by high doses of Vitamin-B. They also pointed out that diabetics in addition to kidney function loss were affected by higher rates of heart attack and stroke than those who took a placebo.

Diabetic nephropathy is kidney disease or damage that is caused by a complication of diabetes. It affects the network of tiny blood vessels in the glomerulus, a structure in the kidney made of capillary blood vessels to filter blood.

To see whether Vitamin-B therapy would slow down the progression of diabetic nephropathy and prevent vascular events, the researchers conducted a clinical research in 238 patients with Type-1 and Type-2 diabetes. The placebo-controlled trial was conducted at 5 university medical centers in Canada between May 2001 and July 2007.

Patients were divided into 2 groups: one group received single tablet of Vitamin-B with folic acid (2.5 mg/d), Vitamin B6 (25 mg/d) and Vitamin B12 (1 mg/d) while the other group were prescribed with matching placebo.

After following the patients for an average period of 31.9 months, researchers found that those with Vitamin-B therapy had a faster reduction rate of kidney function, as compared with those who were on placebo treatment. In addition, those patients with diabetic nephropathy additionally had a higher rate of heart attack and stroke than patients who received placebo.

Would Vitamin Help Diabetics?

For people who are unable to get adequate amount of vitamins and minerals from their diet, taking vitamin supplements could be a feasible alternative to help them meet their nutrition requirements. The elderly, strict vegetarians, people on low-calorie diets and those that are malnourished are some good examples of this type of people.

How about diabetics? Would vitamin help control their condition? Most health organizations associated with diabetes do not advocate using vitamins. In fact, they usually warn against using large doses of vitamins or supplements, which could possibly cause adverse side effects.

In April 28, 2010 edition of the Journal of the American Medical Association (JAMA), researchers from the University of Western Ontario and the Robarts Research Institute in London, Ontario reported that patients with diabetic nephropathy would suffer rapid deterioration of the kidneys if treated with high doses of Vitamin B. Moreover, these patients are likely to face a higher risk of heart attack and stroke than patients who took a placebo.

Diabetic nephropathy is a progressive kidney disease because of longstanding diabetes mellitus, and it is a prime indication for dialysis in many Western countries. Even with the many treatments available right now, about 40 percent of the 21 million Americans who have diabetes still develop diabetic nephropathy.

Prior observational studies have shown that there is an association between high concentrations of plasma total homocysteine and the risk of developing diabetic nephropathy, retinopathy, and vascular diseases, including myocardial infarction and stroke. B-Vitamin therapy using folic acid, Vitamin-B6 and Vitamin-B12 is known to be capable of lowering the plasma concentration of homocysteine.

With an aim to developing a new approach to treatment, the researchers conducted a study to see if B-Vitamin therapy would actually slow progression of diabetic nephropathy and prevent vascular events in 238 patients with Type-1 or Type-2 diabetes. Meanwhile, the placebo-controlled trial was carried out at 5 university medical centers in Canada between May 2001 and July 2007.

Patients were prescribed with single tablet of B-Vitamins with folic acid (2.5 mg/d), Vitamin-B6 (25 mg/d), and Vitamin-B12 (1 mg/d), or matching placebo. After an average period of 31.9 months, patients with Vitamin-B were found to have a faster rate of reduction of kidney filtering and so the kidney function, as compared with those on a placebo course. For patients with the diabetic nephropathy, the risk of heart attack and stroke were also higher than those who took placebo.